磷脂酰肌醇3-激酶,phosphatidylinositol 3-kinase
1)phosphatidylinositol 3-kinase磷脂酰肌醇3-激酶
1.Background &Objective:Phosphatidylinositol 3-kinase(PI3-K)has been implicated in the signaling pathways regulating cell growth by v irtue of its activation in response t o various mitogenic stimuli,but the role of PI3-K in human tumorigenesis has not yet to be defined.背景与目的:磷脂酰肌醇3-激酶(phosphatidylinositol3-kinase,PI3-K)可被多种有丝分裂信号刺激活化,它参与有关细胞生长信号的调控,但其在人类肿瘤中的作用尚不清楚。
2.Objective: To investigate the role ofphosphatidylinositol 3-kinase ( PI3K ) pathway in angiotensin II ( Ang II ) - and insulin-induced protein synthesis, and to study the mediation of this pathway in the phosphorylat ion of 4E-binding protein 1 ( 4E-BP1 ) and p70 S6 kinase in vascular smooth muscle cells.目的：研究磷脂酰肌醇3-激酶(P13K)信号通路对血管紧张素Ⅱ(Ang Ⅱ)与胰岛素(Insulin)诱导的血管平滑肌细胞蛋白质合成的影响，及该信号系统对4E结合蛋白1(4E-BP1)和核糖体蛋白S6激酶磷酸化的介导作用。
3.Objective:To investigate the roles ofphosphatidylinositol 3-kinase(PI3K) in the regulation of expression of vascular endothelial growth factor(VEGF) in hepatocellular carcinoma(HCC) cells.目的:研究磷脂酰肌醇3-激酶(PI3K)信号通路在肝癌细胞血管内皮生长因子(VEGF)表达调控中的作用。
英文短句/例句
1.The Activation of Phosphatidylinositol 3-kinase and Extracellular Signal-regulated Kinase in Human Breast Cancer and the Analysis of Correlation磷脂酰肌醇3-激酶与胞外信号调节激酶在人乳腺癌中的活化及其相关性分析
2.The Expression and Significance of ILK and PI3-k in the Placenta of Preeclampsia;整合素连接激酶及磷脂酰肌醇3-激酶在子痫前期患者胎盘中的表达及意义
3.Involvement of Phosphatidylinositol 3-kinase Signaling in Angiotensin II-and Insulin-induced Hypertrophy of Vascular Smooth Muscle Cells;磷脂酰肌醇3-激酶对血管紧张素II与胰岛素诱导的血管平滑肌细胞肥大的介导作用
4.Effects of alcohol and high-fat diet on the expression of phosphatidylinositol 3-kinese in rat adipose tissue酒精联合高脂饮食对大鼠脂肪组织磷脂酰肌醇3激酶表达的影响
5.The role of phosphoinositide 3-kinase signal pathway in airway smooth muscle cells proliferation in asthma磷脂酰肌醇3激酶途径在哮喘大鼠气道平滑肌细胞增殖中的作用
6.Phosphoinositide-3kinase in Colorectal Carcinoma;磷脂酰肌醇-3激酶与大肠癌发生及发展的关系研究
7.Effect of phosphatidylinositol 3-kinase on inducible nitric oxide synthase in bronchiole epithelial cells of asthmatic rat磷脂酰肌醇3激酶对哮喘大鼠气道上皮细胞诱导型一氧化氮合酶表达的调控作用
8.The Relationship of Leptin with Cell Apoptosis of Colorectal Adenocarcinoma and Nuclear Factor-kappa B, Phosphoinositide-3 Kinase Signal Conducting Pathways;瘦素与结直肠腺癌细胞凋亡及与核因子-κB、磷脂酰肌醇-3激酶信号传导通路的关系
9.Effects of combination of octreotide and wortmannin on proliferation of lung carcinoma cell A549磷脂酰肌醇3激酶通道抑制剂联合生长抑素对人肺癌A549细胞的抑制作用
10.The N-Terminal 24 Amino Acids of p55~(PIK) Regulatory Subunit of Phosphoinositide-3-Kinase Inhibit the Proliferation of Human Hepatic Cancer Cells磷脂酰肌醇-3-激酶调节亚基N末端24个氨基酸对肝癌细胞增殖的抑制
11.Regulation of phosphatidylinositol 3-kinase in skeletal muscle and the effect of exercise on it;磷酯酰肌醇3激酶在骨骼肌中的调节以及运动对它的影响
12.phosphatidyl choline-cholesterol acyltransferase磷脂酰胆碱胆甾醇脂酰转移酶
13.Glypican-3 expression and its correlation with clinicopathological parameters in hepatocellular carcinoma磷脂酰肌醇蛋白多糖-3在肝癌组织中的表达及其临床病理学特征
14.Amplification and clinical value of hepatic glypican-3 mRNA during hepatic cancerization肝细胞癌变过程中磷脂酰肌醇蛋白多糖-3 mRNA扩增及临床价值
15.Molecular Cloning and Functional Analysis of Genes Involved in the Phosphoinositide-Signaling Pathways from Maize;玉米磷脂酰肌醇代谢途径中酶的基因克隆及其功能鉴定
16.The Role of Inositol and Phosphatidylinositol in Invertase Secretion by Derepressed Mutants of Saccharomyces Cerevisiae;肌醇和磷脂酰肌醇在酒精酵母解阻遏突变株蔗糖酶分泌调控中的作用
17.The Primary Study of the Effect of Glycosylphosphatidylinositol-specific Phospholipase D on Anti-atherosclerosis;糖基化磷脂酰肌醇特异性磷脂酶D抗动脉粥样硬化作用的初步研究
18.The Effect of Glycosylphosphatidylinositol-specific Phospholipase D on Glioma Occurrence and Invasion糖基化磷脂酰肌醇特异性磷脂酶D在神经胶质瘤发生与侵袭中的作用
相关短句/例句
PI3K磷脂酰肌醇3-激酶
1.Previous data showed that NOK could activate the phosphatidylinositol 3 -kinase(PI3K) pathway in stable BaF3 cells.前期的研究表明,NOK在小鼠前B细胞(BaF3)中能够激活磷脂酰肌醇3-激酶(PI3K)信号通路。
2.Objective:To investigate the effect of CD151 gene divery on the expression ofPI3K/Akt and hemodynamic variables in rat myocardial infarction model.目的:探讨CD151对大鼠心肌梗死模型缺血心肌磷脂酰肌醇3-激酶表达和血流动力学的影响,阐明其分子机制方法:制作大鼠心肌梗死模型,随机分为四组(假手术组、心肌梗死+生理盐水组、心肌梗死+rAAV-GFP 组、心肌梗死+rAAV-CD151组),分别将生理盐水、携带 GFP 基因、人 CD151基因的重组腺病毒相关病毒(rAAV)载体注入缺血心肌和相应部位。
3)phosphatidylinositol 3-kinase磷脂酰肌醇3激酶
1.Activation ofphosphatidylinositol 3-kinase/protein kinase B induced by trypsin in neutrophils;磷脂酰肌醇3激酶/蛋白激酶B信号转导通路在胰蛋白酶激活中性粒细胞中的作用
2.Objective To explore if the effect of connective tissue growth factor on the transdifferentation of human hypertrophic scar fibroblasts is mediated byphosphatidylinositol 3-kinase/ protein kinase B(PI3K/PKB) signal pathway.目的:探讨磷脂酰肌醇3激酶/蛋白激酶B信号通路是否介导结缔组织生长因子促人增生性瘢痕成纤维细胞转分化。
3.Objective:To study the effect of chronic alcohol intake on expression of PI-3K-p85α (p85 regulatory subunit ofphosphatidylinositol 3-kinase) in skeletal muscle of rats and explore the molecular mechanism of alcohol induced insulin resistance.目的:研究酒精长期作用下对大鼠骨骼肌磷脂酰肌醇3激酶(phosphatidylinositol 3-kinase,PI-3K)调节亚基p85αmRNA及蛋白水平表达的影响,探讨酒精引起胰岛素抵抗的相关分子机制。
4)PI3 K pathway磷脂酰肌醇3激酶通道
5)PI3-Kinase3-磷脂酰肌醇激酶
6)phosphatidylinositol 3-kinase磷脂酰肌醇-3激酶
1.Inhibition of Tirapazamine Combined with Phosphatidylinositol 3-kinase Inhibitor LY294002 to Ovarian Cancer Cells;手性霉素联合磷脂酰肌醇-3激酶抑制剂对人卵巢癌细胞的抑制作用
2.Objective To observe the effect of rosiglitazone on the production of nitric oxide (NO) and the expression ofphosphatidylinositol 3-kinase (PI3K)/protein kinase B(PKB) /the endothelial nitric oxide synthase (eNOS) in cultured human umbilical vein endothelial cells(HUVECs), and to investigate the mechanism of signal transduction of rosiglitazone in improving the endothelial function.目的:观察罗格列酮对人脐静脉内皮细胞(human umbilical vein endothelial cells,HUVEC)一氧化氮(nitric oxide,NO)浓度和内皮型一氧化氮合酶(endothelial nitric oxide synthase,eNOS)、磷脂酰肌醇-3激酶(phosphatidylinositol3-kinase,PI3K)和蛋白激酶B(protein kinase B,PKB)表达的影响,探讨罗格列酮改善内皮功能的信号转导机制。
3.· AIM: To investigate the role ofphosphatidylinositol 3-kinase(PI3K)signal transduction pathway in vascular endothelial growth factor(VEGF)expression in cultured human retinal pigment epithelial(RPE) cells under hypoxia.目的:探讨磷脂酰肌醇-3激酶(phosphatidylinositol3-ki-nase,PI3K)信号转导通路对缺氧诱导的视网膜色素上皮(retinalpigmentepithelium,RPE)细胞表达VEGF的影响。
延伸阅读
4,5-二磷酸磷脂酰肌醇分子式：CAS号：性质：又称三磷酸磷脂酰肌醇，4,5-二磷酸磷脂酰肌醇。是磷脂类化合物之一，前体是磷脂酰肌醇二磷酸。在脑中含量很多，与其前体在体内可互相转换。通常可从牛脑中提取，产品多为其铵盐或钠盐，呈淡黄色冻干粉。R1和R2的脂肪酸组成：16:0约1％；18:0约41％；18:1约30％；18:3约4％；18:4约1％；20:4约1％；20:5约2％；20:6约14％。早期取平均值把R1定为硬脂酸，R2定为花生四烯酸，与实际误差较大。主要用作生化试剂。
