— You look sad. ?— Oh my grandmother’s very ill.A. What’s upB. How are youC. What’s that

问题补充：

— You look sad. ?

— Oh, my grandmother’s very ill.

A. What’s up

B. How are you

C. What’s that

D. How about you

答案：

(答案→)A. What’s up

B. How are you

C. What’s that

D. How about you

解析：What’s up?是一个常用语,意为“怎么回事?”