-What has made him look like lacking sleep?-- his wife is ill and he has to get up

问题补充：

---- What has made him look like lacking sleep?

----- his wife is ill and he has to get up several times a night to attend to her.

A. For

B. Because

C. That

D. What

答案：

A. For

B. Because

(答案→)C. That

D. What

解析：考察主语从句。本题指的that引导主语从句That his wife is ill and he has to get up several times a night to attend to her.在句中不充当任何成分，只起引导和连接作用。AB不能引导主语从句，what要在句中作主语，宾语或者表语。句意：—什么事情让他看起来如此缺少睡眠？—他的妻子生病了，他不得不起床好几次来照顾她。故C正确。