干细胞与人体衰竭器官的再生,这里有最新成果
寻找理想的启动细胞
图片来自视觉中国
使用患者自身干细胞的障碍
从患者自身细胞中产生的干细胞——称为自体干细胞——目前被认为是规避免疫排斥的最有希望的策略。
缺乏免疫功能的细胞可能是解决之道
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参考文献:
[1]De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans
[2]SCNT-Derived ESCs with Mismatched Mitochondria Trigger an Immune Response in Allogeneic Hosts
[3]De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans
[4]Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients