NCBI
美国国立医学图书馆(NLM)于1988年11月4日
建立国家生物技术信息中心(National Center for Biotechnology Information，
简称NCBI)。该中心的主要任务为:
为储存和分析分子生物学、生物化学、遗传学知识创建自动化系统;
从事研究基于计算机的信息处理过程的高级方法，
用于分析生物学上重要的分子和化合物的结构与功能;
促进生物学研究人员和医护人员应用数据库和软件;
努力协作以获取世界范围内的生物技术信息。
NCBI 实验数据
ARONIA
野樱莓改善血管内壁作用和调节肠道微生物群组成
本试验在clinicaltrials.gov注册为NCT03401961
因文中涉及很多专业术语，可能翻译存在误差，具体表述含义以英文为准！
实验背景
BACKGROUND
不老莓富含（多）酚类物质。先前的研究已经证明，这些浆果可能对高危人群的心血管健康有益。然而，很少有研究调查了在健康受试者中每日食用可达到数量的浆果的影响。
研究目标
OBJECTIVES
本研究的目的是研究在健康人群中，不老莓对血管功能和肠道微生物群组成的影响。
实验方法
METHODS
对66名健康男性进行了一项双盲、安慰剂对照、平行设计的研究，这些健康男性被随机分配食用富含苯酚的提取物（116 mg，75 g浆果）、全果粉（12 mg，10 g浆果）或安慰剂（麦芽糖糊精）12周。流介导的扩张（FMD），动脉僵硬度，血压，心率和血清生化进行了评估。采用液相色谱-质谱联用（LC-MS）法分析血浆（多酚）代谢产物，采用16S rRNA测序法测定粪便样品中肠道微生物群的组成。
实验结果
RESULTS
野樱莓浆果和提取粉在12周内的消耗量导致FMD显着增加，分别为0.9%±0.4%（95%CI:0.13%，1.72%）和1.2%±0.4%（95%CI:0.36%，1.97%）。第1天（1.1%±0.3%，p=0.003）和第12周（1.5%±0.4%，p=0.0001）服用野樱莓提取物2小时后，也观察到FMD的急性改善。服用野樱莓后循环血浆中酚类代谢物增加。虽然在肠道微生物群多样性方面没有发现变化，但食用野樱莓提取物可增加厌氧菌的生长（+10.6%，p=0.01），而野樱莓整果类杆菌的生长显着增加（+193%，p=0.01）。相关分析表明，口蹄疫、芳香族衍生酚类代谢物和特定肠道微生物属的变化之间存在显着相关性。
实验结论
CONCLUSIONS
在健康男性中，服用Aronia浆果（poly）酚可改善血管内壁作用和调节肠道微生物群组成，这表明在心血管疾病风险较低的人群中，经常服用Aronia有可能保持心血管健康。
本试验在clinicaltrials.gov注册为NCT03401961。
不老莓英文原稿
Effects of aronia berry (poly)phenols on vascular function and gut microbiota: a double-blind randomized controlled trial in adult men.
BACKGROUND:Aronia melanocarpa is a rich source of (poly)phenols. Previous research has demonstrated that these berries may provide cardiovascular health benefits in high-risk populations. However, very few studies have investigated the effects of daily consumption of dietary achievable amounts of the berries in healthy subjects.OBJECTIVES:The aim of this study was to investigate the effects of aronia berries on vascular function and gut microbiota composition in a healthy population.METHODS:A double-blind, placebo-controlled, parallel designed study was conducted in 66 healthy men randomly allocated to consume a (poly)phenol-rich extract (116 mg, 75 g berries), a whole fruit powder (12 mg, 10 g berries), or placebo (maltodextrin) for 12 wk. Flow-mediated dilation (FMD), arterial stiffness, blood pressure, heart rate, and serum biochemistry were assessed. Plasma (poly)phenol metabolites were analyzed by LC-MS. Gut microbiota composition was determined via 16S rRNA sequencing in stool samples.RESULTS:Consumption of aronia whole fruit and extract powder for 12 wk led to a significant increase in FMD over control of 0.9% ± 0.4% (95% CI: 0.13%, 1.72%) and 1.2% ± 0.4% (95% CI: 0.36%, 1.97%), respectively. Acute improvements in FMD were also observed 2 h after consumption of aronia extract on day 1 (1.1% ± 0.3%, P = 0.003) and 12 wk later (1.5% ± 0.4%, P = 0.0001). Circulating plasma phenolic metabolites increased upon consumption of the aronia treatments. Although no changes were found in gut microbiota diversity, consumption of aronia extract increased the growth of Anaerostipes (+10.6%, P = 0.01), whereas aronia whole fruit showed significant increases in Bacteroides (+193%, P = 0.01). Correlation analysis identified significant associations between changes in FMD, aronia-derived phenolic metabolites, and specific gut microbial genera.CONCLUSIONS:In healthy men, consumption of aronia berry (poly)phenols improved endothelial function and modulated gut microbiota composition, indicating that regular aronia consumption has the potential to maintain cardiovascular health in individuals at low risk of cardiovascular disease. This trial was registered at CLINICALTRIALs.gov as NCT03041961.
提示：不老莓属于健康食品，不能用来治疗任何疾病。
注：图片来源网络
