泛素连接酶,ubiquitin ligase
1)ubiquitin ligase泛素连接酶
1.FBW7: the substrate recognition component of SCF-typeubiquitin ligase;SCF泛素连接酶靶蛋白识别组分FBW7
2.LNX is a novelubiquitin ligase that promotes ubiquitin-mediated degradation of intrinsic cell fate determinant Numb.为阐明泛素连接酶LNX在维持上皮细胞之间连接的作用,构建了四环素诱导表达LNX的MDCK细胞株;以免疫荧光法观察细胞连接蛋白E-钙黏素和ZO-1在细胞内的分布,发现LNX的表达使E-钙黏素和ZO-1在细胞内的分布发生明显改变,大量E-钙黏素和ZO-1聚集在胞浆中,而在细胞膜上的分布则明显减少;透射电镜观察上皮细胞间连接的超微结构显示,LNX的表达导致紧密连接和黏附连接的正常结构消失;用钙离子转换实验检测黏附连接的形成发现,表达LNX的MDCK细胞间的黏附连接形成的速度明显滞后于正常细胞。
英文短句/例句
1.Ufd1 Enhances the Activity of Ubiquitin Ligase gp78;Ufd1增强泛素连接酶gp78活性的研究
2.Hrd1 Facilitates Tau Degradation by Ubiquitin-proteasome Pathway;泛素连接酶Hrd1介导的tau蛋白降解
3.Functional Characteristics on E3 Ubiquitin Ligase SRAR1 in Arabidopsis拟南芥泛素连接酶SRAR1的功能研究
4.Regulation of p53 Family Proteins by HECT-type E3 Ubiquitin LigasesHECT类泛素连接酶对p53家族的调控作用
5.HECT Domain Ubiquitin-protein Ligase Wwp2 Ubiquitinates the Large Subunit of RNA Polymerase II;HECT家族泛素连接酶Wwp2泛素化修饰RNA聚合酶II大亚基Rpb1
6.The Effects of Various Recombined Chimeric Cbl Ubiquitin Ligases on the Growth of Tumour Cells;重组嵌合Cbl泛素连接酶对肿瘤细胞生长的影响
7.Effects of the Ubiquitin Ligase Pirh2 in Inhibiting Cell Growth of Lung Cancer;泛素连接酶Pirh2抑制肺癌细胞生长的试验研究
8.hHrd1, a Ubiquitin Protein Ligase s Expression in Parkinson s Disease Rat Model and It s Significance;泛素连接酶hHrd1在帕金森病大鼠模型中的表达及其意义
9.Overexpression of E3 Ubiquitin Ligase CHIP Induces Mitotic Catastrophe in K562 Cells;过表达E3泛素连接酶CHIP诱导K562细胞有丝分裂灾变
10.Tau-mediated Cell Toxicity and the Protection of Ubiquitin Ligase Hrd1 Against It;Tau蛋白介导的细胞毒性及泛素连接酶Hrd1的保护作用
11.Effects of E3 Ubiquitin Ligase APC on Expression of SnoN in Renal Tissue of Diabetic RatsE3泛素连接酶APC对糖尿病大鼠肾组织SnoN蛋白表达的影响
12.The Regulatory Mechanism of PI3K/Akt and Ubiquitin Ligase Cbl-b in Bufalin-induced Human Gastric Cancer Cell Apoptosis;PI3K/Akt通路及泛素连接酶Cbl-b调控蟾蜍灵诱导胃癌细胞凋亡机制的研究
13.Muscle-specific Ubiquitin-protein Ligase is Important in Cancer Cachexia: Based on Basic and Clinincal Studies;肌肉细胞特异性泛素蛋白连接酶在癌性恶液质中作用机制的研究
14.Progress in regulation of activity and stability of ubiquitin protein ligase MDM2泛素蛋白连接酶MDM2活性及稳定性调控的研究进展
15.Function and significance of integrin-linked kinase in heart整合素连接激酶在心脏中的功能意义
16.amino acid RNA ligase氨基酸rna连接酶
17.Expression and Significance of Integrin Linked Kinase (ILK) in Pancreatic Adenocarcinoma整合素连接激酶（ILK）在胰腺癌中的表达及意义
18.Expression and Function of Integrin-linked Kinase-associated Phosphatase (ILKAP)整合素连接激酶相关磷酸酶（ILKAP）的表达与功能分析
相关短句/例句
ubiquitin-protein ligase(E3 ligase)泛素连接酶(E3连接酶)
3)ubiquitin ligase E3泛素连接酶E3
4)E3 ubiquitin protein ligase泛素蛋白连接酶
1.Now it is believed that Parkin functions as anE3 ubiquitin protein ligase which involves in protein s ubiquitination.现认为Parkin行使泛素蛋白连接酶功能,参与蛋白质的泛素化过程。
5)E3 ubiquitin ligaseE3泛素连接酶
1.As key members of the protein degradation enzymatic system, the function ofE3 ubiquitin ligases has been extensively investigated.作为该系统中行使调控降解功能的核心成员,E3泛素连接酶的重要作用已经越来越引起人们的重视。
6)Ubiquitin-protein ligases(E3)泛素-蛋白连接酶
延伸阅读
连接酶分子式：CAS号：性质：一种酶能催化两个不同分子或同一分子的两端的连接，此反应与ATP的分解反应相偶联。连接酶是酶分类中重要的一类(EC 6):6.1形成C-O键；6.2形成C-S键；6.3形成C-N键；6.4 形成C-C键。
