研究揭示酵母细胞衰老的命运决定基础 作者： 发布时间：/7/18 8:08:42 7月17日出版的《科学》杂志发表了美国加州大学圣地亚哥分校Nan Hao研究团队的最新成果，他们的研究揭示了酵母细胞衰老的命运决定基础。
研究人员发现，染色质沉默和线粒体途径之间的相互作用导致了酵母复制衰老的表观遗传学改变并存在多个平衡状态，这些状态代表了不同类型的衰老终态。表观遗传结构在衰老过程中将单细胞分化为这些状态之一，从而决定了命运，而且对细胞内的噪音不敏感。在衰老的定量模型下，研究人员通过基因工程设计了长寿命的平衡状态，并成功实现寿命延长。
据了解，染色质不稳定和线粒体衰退是导致细胞衰老的保守过程。尽管这两个过程已在其独特的信号传导途径中进行了单独探讨，但尚不清楚确定单个细胞衰老过程中哪个过程占主导地位。
附：英文原文
Title: A programmable fate decision landscape underlies single-cell aging in yeast
Author: Yang Li, Yanfei Jiang, Julie Paxman, Richard O Laughlin, Stephen Klepin, Yuelian Zhu, Lorraine Pillus, Lev S. Tsimring, Jeff Hasty, Nan Hao
Issue Volume: /07/17
Abstract: Chromatin instability and mitochondrial decline are conserved processes that contribute to cellular aging. Although both processes have been explored individually in the context of their distinct signaling pathways, the mechanism that determines which process dominates during aging of individual cells is unknown. We show that interactions between the chromatin silencing and mitochondrial pathways lead to an epigenetic landscape of yeast replicative aging with multiple equilibrium states that represent different types of terminal states of aging. The structure of the landscape drives single-cell differentiation toward one of these states during aging, whereby the fate is determined quite early and is insensitive to intracellular noise. Guided by a quantitative model of the aging landscape, we genetically engineered a long-lived equilibrium state characterized by an extended life span.
DOI: 10.1126/science.aax9552
Source:
期刊信息 Science：《科学》，创刊于1880年。隶属于美国科学促进会，最新IF：41.037官方网址：投稿链接：
