寨卡病毒感染增加严重登革热风险 作者： 发布时间：/8/28 16:46:14 美国加利福尼亚大学Eva Harris研究组近日取得一项新成果。他们的最新研究揭示寨卡病毒（ZIKV）感染增加了严重登革热的未来风险。8月28日出版的《科学》杂志发表了这一成果。
他们研究了尼加拉瓜的前瞻性儿科病例，这些病例连续经历了登革热病毒DENV1至-3（至），Zika（至）和DENV2（至）的爆发。与单纯黄病毒相比，ZIKV感染之前，先有ZIKV、DENV或DENV感染，增加了有症状DENV2感染和严重疾病的风险。相比之下，先前的多次DENV感染减少了登革热的风险。
此外，尽管先前存在的高抗DENV抗体滴度可抵御DENV1、DENV3和ZIKV疾病，但之前的ZIKV或DENV感染诱导的中间滴度可提高DENV2疾病和严重程度以及DENV3严重性的未来风险。先前的ZIKV感染可以像DENV血清型一样调节登革热疾病严重性的观察结果，对登革热和Zika疫苗的研发提出了挑战。
据悉，寨卡病毒大流行引起了人们的浓厚兴趣，即登革热病毒血清型1至4（DENV1至-4）之间的免疫相互作用是否扩展到密切相关的ZIKV。
附：英文原文
Title: Zika virus infection enhances future risk of severe dengue disease
Author: Leah C. Katzelnick, C sar Narvaez, Sonia Arguello, Brenda Lopez Mercado, Damaris Collado, Oscarlett Ampie, Douglas Elizondo, Tatiana Miranda, Fausto Bustos Carillo, Juan Carlos Mercado, Krista Latta, Amy Schiller, Bruno Segovia-Chumbez, Sergio Ojeda, Nery Sanchez, Miguel Plazaola, Josefina Coloma, M. Elizabeth Halloran, Lakshmanane Premkumar, Aubree Gordon, Federico Narvaez, Aravinda M. de Silva, Guillermina Kuan, Angel Balmaseda, Eva Harris
Issue Volume: /08/28
Abstract: The Zika pandemic sparked intense interest in whether immune interactions among dengue virus serotypes 1 to 4 (DENV1 to -4) extend to the closely related Zika virus (ZIKV). We investigated prospective pediatric cohorts in Nicaragua that experienced sequential DENV1 to -3 ( to ), Zika ( to ), and DENV2 ( to ) epidemics. Risk of symptomatic DENV2 infection and severe disease was elevated by one prior ZIKV infection, one prior DENV infection, or one prior DENV infection followed by one ZIKV infection, compared with being flavivirus-nave. By contrast, multiple prior DENV infections reduced dengue risk. Further, although high preexisting anti-DENV antibody titers protected against DENV1, DENV3, and ZIKV disease, intermediate titers induced by previous ZIKV or DENV infection enhanced future risk of DENV2 disease and severity, as well as DENV3 severity. The observation that prior ZIKV infection can modulate dengue disease severity like a DENV serotype poses challenges to development of dengue and Zika vaccines.
DOI: 10.1126/science.abb6143
Source:
期刊信息 Science：《科学》，创刊于1880年。隶属于美国科学促进会，最新IF：41.037官方网址：投稿链接：
